Research Focus and Main research questions
We address the role of the innate and the adaptive immune system in hypertension and hypertensive end organ damage by examining the following points:
1. Role of complement in arterial hypertension
2. Role of the mineralocorticoid and AT1 receptor in inflammatory cells.
So called malignant nephrosclerosis, defined as renal microangiopathy in the setting of severe hypertension leads to end-stage renal disease in a considerable proportion of patients despite good blood pressure control. The mechanisms causing transition from high blood pressure to malignant hypertension with malignant nephrosclerosis and renal failure are completely unknown. We use biased and unbiased approaches to examine the underlying mechanisms in human tissue.