Research Focus and Main research questions
The regenerative capacity of the heart is limited. After a brief postnatal period during which the heart is able to (partially) regenerate, cardiac injury leads to the formation of scar tissue and often results in heart failure. Even though modern pharmacotherapy has increased life expectancy significantly for heart failure patients it does not address the underlying problem, the loss of cardiomyocytes. Our research aims to develop regenerative pharmacological strategies. It mainly focuses on translational studies to apply pluripotent stem cell-based strategies for cardiac regeneration but also uses stem cell-based cardiac tissue engineering to model human cardiac injury and regeneration in a dish to identify new targets for cardiac repair.