Research Focus and Main research questions
Our research group has been established in 2021 to explore the utility of biomarkers and genomics in cardiovascular health and disease.
A wide range of biomarkers, not limited to circulating molecules in the blood but also integrating vital signs, ECG and imaging data, are linked with cardiovascular disease and future cardiovascular events. We aim to assess the diagnostic and prognostic utility of established and emerging biomarkers in large-scale clinical and epidemiological datasets. With the aid of advanced statistical models including machine-based learning, biomarkers will be considered in a holistic approach in order to enable best incremental value in clinical practice.
As a center piece of this research group, whole genome sequencing data will be obtained from 8‘000 apparently healthy individuals from the Hamburg City Health Study (HCHS) and 1‘000 patients with cardiovascular disease. This unique dataset with most detailed phenotyping will provide the basis to study the impact of genomics on cardiovascular health, test for risk prediction models and identify novel therapeutic targets.