Research Focus and Main research questions
Diabetes mellitus is increasing worldwide and is the most important risk factor for the development of cardiovascular diseases. Thus, we mainly investigate the molecular pathogenesis of this disease. Our previous work showed that the dual leucine zipper kinase (DLK, MAP3K12) becomes activated by prediabetic signals and interferes with the function of insulin producing beta-cells. We now ask whether the inhibition of this kinase prevents diabetes mellitus and aim to identify novel DLK inhibitors. In addition, we investigate the role of the transcriptional coactivator CRTC1 in the development of cardiovascular diseases.