Linda Diehl
Prof. Dr.
Linda Diehl
  • Deputy director of the institute
Working area


Campus Forschung N27 , Ground Floor, Room number 00.098
Dutch (Mother tongue)



Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C, Milde-Langosch K, Oliveira-Ferrer L, Ricklefs F, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnenberger H, Offermann A, Perner S, Sebens S, Lamszus K, Diehl L, Linder S, Jücker M, Schumacher U, Lange T
J HEMATOL ONCOL. 2023;16(1):.


The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability
Geers B, Hagenstein J, Endig J, Ulrich H, Fleig L, Sprezyna P, Mikulec J, Heukamp L, Tiegs G, Diehl L
CELLS-BASEL. 2022;11(17):.

Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8+ T Cells
Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz O, Diehl L, Tiegs G, Neumann K
CELLS-BASEL. 2022;11(9):.


Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
Horst A, Kumashie K, Neumann K, Diehl L, Tiegs G
CELL MOL IMMUNOL. 2021;18(1):92-111.

Comparison of Resistance Spectra after First and Second Line Osimertinib Treatment Detected by Liquid Biopsy
Jóri B, Schatz S, Kaller L, Kah B, Roeper J, Ramdani H, Diehl L, Hoffknecht P, Grohé C, Griesinger F, Tiemann M, Heukamp L, Falk M
CANCERS. 2021;13(12):.

Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras LSL-G12V Driven Lung Cancer Mouse Model
Meder L, Florin A, Ozretić L, Nill M, Koker M, Meemboor S, Radtke F, Diehl L, Ullrich R, Odenthal M, Büttner R, Heukamp L

Immune related endonucleases and GTPases are not associated with tumor response in patients with advanced non-small cell lung cancer treated with checkpoint inhibitors
Ramdani H, Falk M, Heukamp L, Schatz S, Tiemann M, Wesseler C, Diehl L, Schuuring E, Groen H, Griesinger F
PATHOL RES PRACT. 2021;227:.

Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl4 Exposure in Mice
Unrau L, Endig J, Goltz D, Sprezyna P, Ulrich H, Hagenstein J, Geers B, Kaftan K, Heukamp L, Tiegs G, Diehl L
INT J MOL SCI. 2021;22(21):.


TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC
Roeper J, Falk M, Chalaris-Rißmann A, Lueers A, Ramdani H, Wedeken K, Stropiep U, Diehl L, Tiemann M, Heukamp L, Otto-Sobotka F, Griesinger F
ONCOTARGET. 2020;11(3):250-264.

Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer
Schatz S, Falk M, Jóri B, Ramdani H, Schmidt S, Willing E, Menon R, Groen H, Diehl L, Kröger M, Wesseler C, Griesinger F, Hoffknecht P, Tiemann M, Heukamp L
CANCERS. 2020;12(6):.

Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis
Schulte R, Wohlleber D, Unrau L, Geers B, Metzger C, Erhardt A, Tiegs G, van Rooijen N, Heukamp L, Klotz L, Knolle P, Diehl L
INT J MOL SCI. 2020;21(7):.


Acute Liver Injury after CCl4 Administration is Independent of Smad7 Expression in Myeloid Cells
Endig J, Unrau L, Sprezyna P, Rading S, Karsak M, Goltz D, Heukamp L, Tiegs G, Diehl L
INT J MOL SCI. 2019;20(22):.

Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease
Horst A, Tiegs G, Diehl L
FRONT IMMUNOL. 2019;10:2670.


Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
Horst A, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert A, Oldhafer K, Weiler-Normann C, Lang K, Singer B, Altfeld M, Diehl L, Tiegs G
HEPATOLOGY. 2018;68(1):200-214.

The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production
Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp L, Knolle P, Kolanus W, Diehl L
SCI REP-UK. 2018;8(1):16123.


Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination
Heine A, Flores C, Gevensleben H, Diehl L, Heikenwälder M, Ringelhan M, Janssen K, Nitsche U, Garbi N, Brossart P, Knolle P, Kurts C, Höchst B
ONCOIMMUNOLOGY. 2017;6(8):e1338995.


Loss of the LIM-only protein Fhl2 impairs inflammatory reaction and scar formation after cardiac ischemia leading to better hemodynamic performance
Goltz D, Hittetiya K, Gevensleben H, Kirfel J, Diehl L, Meyer R, Büttner R
LIFE SCI. 2016;151:348-58.

The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib
Heine A, Schilling J, Grünwald B, Krüger A, Gevensleben H, Held S, Garbi N, Kurts C, Brossart P, Knolle P, Diehl L, Höchst B
CANCER IMMUNOL IMMUN. 2016;65(3):273-82.

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells
Horst A, Neumann K, Diehl L, Tiegs G
CELL MOL IMMUNOL. 2016;13(3):277-292.


Immunomodulation by splenectomy or by FTY720 protects the heart against ischemia reperfusion injury
Goltz D, Huss S, Ramadori E, Büttner R, Diehl L, Meyer R
CLIN EXP PHARMACOL P. 2015;42(11):1168-77.

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis
Höchst B, Mikulec J, Baccega T, Metzger C, Welz M, Peusquens J, Tacke F, Knolle P, Kurts C, Diehl L, Ludwig-Portugall I
PLOS ONE. 2015;10(3):Art. e0119662.


Immunological in vivo effects of B7-H1 deficiency
Bazhin A, von Ahn K, Maier C, Soltek S, Serba S, Diehl L, Werner J, Karakhanova S
IMMUNOL LETT. 2014;162(2 Pt B):273-86.

Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time
Kaczmarek J, Homsi Y, van Üüm J, Metzger C, Knolle P, Kolanus W, Lang T, Diehl L
PLOS ONE. 2014;9(6):e99574.


Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity
Böttcher J, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Höchst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath M, Busch D, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze J, Diehl L, Knolle P
CELL REP. 2013;3(3):779-95.

Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model
König K, Meder L, Kröger C, Diehl L, Florin A, Rommerscheidt-Fuss U, Kahl P, Wardelmann E, Magin T, Buettner R, Heukamp L
PLOS ONE. 2013;8(3):e57996.


Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice
Höchst B, Schildberg F, Böttcher J, Metzger C, Huss S, Türler A, Overhaus M, Knoblich A, Schneider B, Pantelis D, Kurts C, Kalff J, Knolle P, Diehl L
HEPATOLOGY. 2012;56(5):1924-33.

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
Sprüssel A, Schulte J, Weber S, Necke M, Händschke K, Thor T, Pajtler K, Schramm A, König K, Diehl L, Mestdagh P, Vandesompele J, Speleman F, Jastrow H, Heukamp L, Schüle R, Dührsen U, Buettner R, Eggert A, Göthert J
LEUKEMIA. 2012;26(9):2039-51.


Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism
Schildberg F, Wojtalla A, Siegmund S, Endl E, Diehl L, Abdullah Z, Kurts C, Knolle P
HEPATOLOGY. 2011;54(1):262-72.


Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity
Kern M, Popov A, Scholz K, Schumak B, Djandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase M, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle P
GASTROENTEROLOGY. 2010;138(1):336-46.

Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration
König K, Diehl L, Rommerscheidt-Fuss U, Golletz C, Quast T, Kahl P, Kolanus W, Knolle P, Buettner R, Heukamp L
J IMMUNOL. 2010;185(3):1466-75.

Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells
Schurich A, Berg M, Stabenow D, Böttcher J, Kern M, Schild H, Kurts C, Schuette V, Burgdorf S, Diehl L, Limmer A, Knolle P
J IMMUNOL. 2010;184(8):4107-14.


Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
Linnemann C, Schildberg F, Schurich A, Diehl L, Hegenbarth S, Endl E, Lacher S, Müller C, Frey J, Simeoni L, Schraven B, Stabenow D, Knolle P
IMMUNOLOGY. 2009;128(1 Suppl):e728-37.

Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization
von Oppen N, Schurich A, Hegenbarth S, Stabenow D, Tolba R, Weiskirchen R, Geerts A, Kolanus W, Knolle P, Diehl L
HEPATOLOGY. 2009;49(5):1664-72.


Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance
Diehl L, Schurich A, Grochtmann R, Hegenbarth S, Chen L, Knolle P
HEPATOLOGY. 2008;47(1):296-305.

The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen
Lukacs-Kornek V, Burgdorf S, Diehl L, Specht S, Kornek M, Kurts C
J IMMUNOL. 2008;180(2):706-15.


Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy
Klotz L, Dani I, Edenhofer F, Nolden L, Evert B, Paul B, Kolanus W, Klockgether T, Knolle P, Diehl L
J IMMUNOL. 2007;178(4):2122-31.

Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro
Klotz L, Diehl L, Dani I, Neumann H, von Oppen N, Dolf A, Endl E, Klockgether T, Engelhardt B, Knolle P
J NEUROIMMUNOL. 2007;190(1-2):34-43.


Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure
Schmitz V, Dombrowski F, Prieto J, Qian C, Diehl L, Knolle P, Sauerbruch T, Caselmann W, Spengler U, Leifeld L
HEPATOLOGY. 2006;44(2):430-9.

Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells
Wingender G, Berg M, Jüngerkes F, Diehl L, Sullivan B, Kronenberg M, Limmer A, Knolle P
EUR J IMMUNOL. 2006;36(3):570-82.


In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway
Diehl L, van Mierlo G, den Boer A, van der Voort E, Fransen M, van Bostelen L, Krimpenfort P, Melief C, Mittler R, Toes R, Offringa R
J IMMUNOL. 2002;168(8):3755-62.


Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance
den Boer A, Diehl L, van Mierlo G, van der Voort E, Fransen M, Krimpenfort P, Melief C, Offringa R, Toes R
J IMMUNOL. 2001;167(5):2522-8.

Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis
Schurmans L, Diehl L, den Boer A, Sutmuller R, Boonman Z, Medema J, van der Voort E, Laman J, Melief C, Jager M, Toes R
J IMMUNOL. 2001;167(10):5832-7.


The role of CD40 in peripheral T cell tolerance and immunity
Diehl L, Den Boer A, van der Voort E, Melief C, Offringa R, Toes R
J MOL MED. 2000;78(7):363-71.


CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
Diehl L, den Boer A, Schoenberger S, van der Voort E, Schumacher T, Melief C, Offringa R, Toes R
NAT MED. 1999;5(7):774-9.

Successful immunotherapy of an intraocular tumor in mice
Schurmans L, den Boer A, Diehl L, van der Voort E, Kast W, Melief C, Toes R, Jager M
CANCER RES. 1999;59(20):5250-4.

Letzte Aktualisierung aus dem FIS: 21.05.2024 - 04:53 Uhr