Andrea Horst
Priv.-Doz. Dr. rer. nat.
Andrea Kristina Horst
Working area


Campus Forschung N27 , Ground Floor, Room number 00.105
German (Mother tongue)



TNF in the liver:targeting a central player in inflammation
Tiegs G, Horst A
SEMIN IMMUNOPATHOL. 2022;44(4):445-459.


Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
Horst A, Kumashie K, Neumann K, Diehl L, Tiegs G
CELL MOL IMMUNOL. 2021;18(1):92-111.


ALCAM contributes to brain metastasis formation in non-small-cell lung cancer through interaction with the vascular endothelium
Münsterberg J, Loreth D, Brylka L, Werner S, Karbanova J, Gandrass M, Schneegans S, Besler K, Hamester F, Robador J, Bauer A, Werner Schneider S, Wrage M, Lamszus K, Matschke J, Vashist Y, Uzunoglu G, Steurer S, Horst A, Oliveira-Ferrer L, Glatzel M, Schinke T, Corbeil D, Pantel K, Maire C, Wikman H
NEURO-ONCOLOGY. 2020;22(7):955-966.


Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease
Horst A, Tiegs G, Diehl L
FRONT IMMUNOL. 2019;10:2670.

Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy
Schirbel A, Rebert N, Sadler T, West G, Rieder F, Wagener C, Horst A, Sturm A, de la Motte C, Fiocchi C
INFLAMM BOWEL DIS. 2019;25(2):294-305.


Endothelial barrier function is differentially regulated by CEACAM1-mediated signaling
Ghavampour S, Kleefeldt F, Bömmel H, Volland J, Paus A, Horst A, Pfeiffer V, Hübner S, Wagner N, Rueckschloss U, Ergün S
FASEB J. 2018;32(10):5612-5625.

CEACAM1 in Liver Injury, Metabolic and Immune Regulation
Horst A, Najjar S, Wagener C, Tiegs G
INT J MOL SCI. 2018;19(10):3110.

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
Horst A, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert A, Oldhafer K, Weiler-Normann C, Lang K, Singer B, Altfeld M, Diehl L, Tiegs G
HEPATOLOGY. 2018;68(1):200-214.


A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
Neumann K, Karimi K, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst A, Tiegs G
J IMMUNOL. 2017;198(1):128-137.


Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells
Horst A, Neumann K, Diehl L, Tiegs G
CELL MOL IMMUNOL. 2016;13(3):277-292.

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, Logsdon M, Brandner J, Tiegs G, Beauchemin N, Wagener C, Deppert W, Horst A
ONCOTARGET. 2016;7(39):63730-63746.


Activation of Cell Surface Bound 20S Proteasome Inhibits Vascular Cell Growth and Arteriogenesis
Ito W, Lund N, Zhang Z, Buck F, Lellek H, Horst A, Machens H, Schunkert H, Schaper W, Meinertz T
BIOMED RES INT . 2015;2015:719316.

Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells
Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall R, Mautner A, Duchstein L, Otto B, Horst A, Amling M, Kreienkamp H, Schinke T
J IMMUNOL. 2015;195(8):3675-84.

Ultrafast extraction of proteins from tissues using desorption by impulsive vibrational excitation
Kwiatkowski M, Wurlitzer M, Omidi M, Ren L, Kruber S, Nimer R, Robertson W, Horst A, Miller R, Schlüter H
ANGEW CHEM INT EDIT. 2015;54(1):285-8.

Inside Cover: Microdomain Formation Controls Spatiotemporal Dynamics of Cell-Surface Glycoproteins (ChemBioChem 14/2015)
Möckl L, Horst A, Kolbe K, Lindhorst T, Bräuchle C
CHEMBIOCHEM. 2015;16(14):1966.

Microdomain Formation Controls Spatiotemporal Dynamics of Cell-Surface Glycoproteins
Möckl L, Horst A, Kolbe K, Lindhorst T, Bräuchle C
CHEMBIOCHEM. 2015;16(14):2023-8.

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation
Solano M, Kowal M, O'Rourke G, Horst A, Modest K, Plösch T, Barikbin R, Remus C, Berger R, Jago C, Ho H, Sass G, Parker V, Lydon J, DeMayo F, Hecher K, Karimi K, Arck P
J CLIN INVEST. 2015;125(4):1726-38.


Increased Osteoclastogenesis in Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1
Heckt T, Bickert T, Jeschke A, Seitz S, Schulze J, Ito W, Zimmermann W, Amling M, Schinke T, Horst A, Keller J
PLOS ONE. 2014;9(12):e114360.

CEA a thrombus CAM: CEACAM2, a twin of CEACAM1?
Horst A
BLOOD. 2014;124(15):2323-4.

CEACAM1 confers resistance toward oxygen-induced vessel damage in a mouse model of retinopathy of prematurity
Ludewig P, Flachsbarth K, Wegscheid C, Tiegs G, Richard G, Wagener C, Bartsch U, Horst A
INVEST OPHTH VIS SCI. 2014;55(12):7950-7960.


Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke
Ludewig P, Sedlacik J, Gelderblom M, Bernreuther C, Korkusuz Y, Wagener C, Gerloff C, Fiehler J, Magnus T, Horst A
CIRC RES. 2013;113(8):1013-22.


Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/⁺Gr-1⁺ myeloid cells--brief report
Bickert T, Marshall R, Zhang Z, Ludewig P, Binder M, Klinke A, Rottbauer W, Amling M, Wagener C, Ito W, Horst A
ARTERIOSCL THROM VAS. 2012;32(11):2566-8.

Transgenic over-expression of interleukin-33 in osteoblasts results in decreased osteoclastogenesis.
Keller J, Catalá-Lehnen P, Wintges K, Schulze J, Bickert T, Ito W, Horst A, Amling M, Schinke T
BIOCHEM BIOPH RES CO. 2012;417(1):217-222.

Antigen-specificity of oligoclonal abnormal protein bands in multiple myeloma after allogeneic stem cell transplantation.
Rahlff J, Trusch M, Haag F, Bacher U, Horst A, Schlüter H, Binder M
CANCER IMMUNOL IMMUN. 2012;61(10):1639-1651.

XMRV induces cell migration, cytokine expression and tumor angiogenesis: are 22Rv1 cells a suitable prostate cancer model?
Stieler K, Schumacher U, Horst A, Fischer N
PLOS ONE. 2012;7(7):42321.


CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation.
Gerstel D, Wegwitz F, Jannasch K, Ludewig P, Scheike K, Alves F, Beauchemin N, Deppert W, Wagener C, Horst A
ONCOGENE. 2011;30(41):4275-4288.

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells.
Schulze J, Bickert T, Beil F, Zaiss M, Albers J, Wintges K, Streichert T, Klätschke K, Keller J, Hissnauer T, Spiro A, Gessner A, Schett G, Amling M, McKenzie A, Horst A, Schinke T
J BONE MINER RES. 2011;26(4):704-717.


A kit for the investigation of live Escherichia coli cell adhesion to glycosylated surfaces.
Hartmann M, Horst A, Klemm P, Lindhorst T
CHEM COMMUN. 2010;46(2):330-332.


CEACAM1+ myeloid cells control angiogenesis in inflammation.
Horst A, Bickert T, Brewig N, Ludewig P, van Rooijen N, Schumacher U, Beauchemin N, Ito W, Fleischer B, Wagener C, Ritter U
BLOOD. 2009;113(26):6726-6736.

Bitter sweetness of complexity
Horst A, Wagener C
TOPICS CURR CHEM. 2009;288:1-15.

DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools.
Samsen A, Bogoevska V, Klampe B, Bamberger A, Lucka L, Horst A, Nollau P, Wagener C

TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis.
Schultze A, Decker S, Wellbrock J, Horst A, Vohwinkel G, Schuch G, Bokemeyer C, Loges S, Fiedler W


CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues.
Bogoevska V, Horst A, Klampe B, Lucka L, Wagener C, Nollau P
GLYCOBIOLOGY. 2006;16(3):197-209.

Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo.
Horst A, Ito W, Dabelstein J, Schumacher U, Sander H, Claire T, Brümmer J, Meinertz T, Beauchemin N, Wagener C
J CLIN INVEST. 2006;116(6):1596-1605.


CEACAM1 enhances invasion and migration of melanocytic and melanoma cells.
Ebrahimnejad A, Streichert T, Nollau P, Horst A, Wagener C, Bamberger A, Brümmer J
AM J PATHOL. 2004;165(5):1781-1787.

CEA-Related CAMs
Horst A, Wagener C
Handb Exp Pharmacol. 2004;(165):283-341.


Binding inhibition of type 1 fimbriae to human granulocytes: a flow cytometric inhibition assay using trivalent cluster mannosides.
Horst A, Kötter S, Lindhorst T, Ludwig A, Brandt E, Wagener C
MED MICROBIOL IMMUN. 2001;190(3):145-149.


CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor.
Ergün S, Kilik N, Ziegeler G, Hansen A, Nollau P, Götze J, Wurmbach J, Horst A, Weil J, Fernando M, Wagener C
MOL CELL. 2000;5(2):311-320.

Letzte Aktualisierung aus dem FIS: 21.05.2024 - 04:32 Uhr