Statistical methods for diagnostic studies

An effective therapy requires a correct diagnosis. For this you need diagnostic tests which are evaluated in so-called diagnostic studies. The development of statistical methods for planning and analyzing diagnostic studies and diagnostic meta-analysis was neglected a long time. Therefore, we aim to close the still existing methodological gaps. Currently we are working on the development of flexible designs for diagnostic studies within the DFG-project entitled

Adaptive (seamless) designs for real-time evaluation

and their utility for parameterizing dynamic infection propagation models in epidemic and parametric settings.

Missing values and estimands in diagnostic studies

The project aims to transfer the concept of Estimands from therapeutic to diagnostic studies.

Completed projects